Galectin Levels and Kidney Damage in Multiple Myeloma Patients
Author Information
Author(s): Carvalho Lidiane Vasconcelos do Nascimento, Assis Reijane Alves, Montenegro Claudio, da Rosa Michelle Melgarejo, Pereira Michelly Cristiny, Pitta Maira Galdino da Rocha, de Melo Rêgo Moacyr Jesus Barreto, Capasso Domenica, Pedone EmiliaMaria, Di Gaetano Sonia
Primary Institution: Research Center for Therapeutic Innovation (NUPIT-SG), Federal University of Pernambuco, Recife, Brazil
Hypothesis
This study aimed to assess the plasma levels of galectins in newly diagnosed multiple myeloma patients and explore their correlation with clinical parameters.
Conclusion
Elevated galectin levels are indicative of disease aggressiveness and renal impairment in multiple myeloma patients.
Supporting Evidence
- Plasma levels of galectins-3, -7, and -9 were significantly higher in multiple myeloma patients compared to the control group.
- Three clusters of multiple myeloma patients were identified based on galectin plasma levels, with one cluster associated with a worse prognosis.
- A strong positive correlation was found between galectin-1, -4, and -7 levels and markers of kidney function.
- Galectin-9 showed high accuracy in distinguishing multiple myeloma patients from healthy controls (AUC = 0.931).
- Elevated galectin levels were indicative of disease aggressiveness and renal impairment in multiple myeloma patients.
Takeaway
The study found that higher levels of certain proteins called galectins in the blood can show how serious the disease is and how it affects the kidneys in patients with multiple myeloma.
Methodology
Plasma levels of galectins were measured using ELISA in blood samples from newly diagnosed multiple myeloma patients.
Participant Demographics
Among the 47 patients, there was a slight male predominance, with a median age of 60 years.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI: 0.875–0.988
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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