Genetic Factors in SARS Susceptibility
Author Information
Author(s): Chong Wai Po, Ip WK Eddie, Tso Gloria Hoi Wan, Ng Man Wai, Wong Wilfred Hing Sang, Law Helen Ka Wai, Yung Raymond WH, Chow Eudora Y, Au KL, Chan Eric YT, Lim Wilina, Peiris JS Malik, Lau Yu Lung
Primary Institution: The University of Hong Kong
Hypothesis
The polymorphisms of the cytokine genes might be associated with SARS susceptibility.
Conclusion
The IFN-γ +874A allele is a significant risk factor for SARS susceptibility.
Supporting Evidence
- The IFN-γ +874A allele was overrepresented in SARS patients compared to controls.
- Individuals with the AA genotype had a 5.19-fold increased risk of developing SARS.
- Individuals with the AT genotype had a 2.57-fold increased risk of developing SARS.
Takeaway
Some people are more likely to get sick from SARS because of their genes, especially if they have a specific version of a gene called IFN-γ.
Methodology
A case-control study comparing 476 SARS patients with 449 healthy controls, genotyping specific cytokine gene polymorphisms.
Limitations
The study did not find significant associations for IL-10 and TNF-α SNPs, and other SNPs may also be involved.
Participant Demographics
476 Chinese SARS patients (201 male, mean age = 39.8) and 449 healthy controls (273 male, mean age = 29.1).
Statistical Information
P-Value
<0.001
Confidence Interval
95% CI, 2.78-9.68 for AA genotype; 95% CI, 1.35-4.88 for AT genotype.
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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