Effect of P-glycoprotein on flavopiridol sensitivity
2001
Effect of P-glycoprotein on flavopiridol sensitivity
publication
Evidence: moderate
Author Information
Author(s): Boerner S A, Tourne M E, Kaufmann S H, Bible K C
Primary Institution: Mayo Clinic and Department of Molecular Pharmacology, Mayo Graduate School
Hypothesis
P-glycoprotein may play a role in flavopiridol resistance.
Conclusion
P-glycoprotein has a modest effect on flavopiridol action, and higher levels of Pgp reduce the drug's toxicity.
Supporting Evidence
- Flavopiridol was less toxic to cells expressing higher levels of Pgp.
- Pretreatment with Pgp inhibitors sensitized CHRC5 cells to flavopiridol.
Takeaway
This study found that a protein called P-glycoprotein can make a cancer drug called flavopiridol less effective.
Methodology
The study examined flavopiridol sensitivity in Chinese hamster ovary cell lines with different levels of P-glycoprotein expression.
Statistical Information
P-Value
<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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