Investigation Between the S377G GATA-4 Polymorphism and Migraine
2008
GATA-4 Gene and Migraine Study
Sample size: 550
publication
Evidence: low
Author Information
Author(s): Sherin Chikhani, Francesca Fernandez, Karl Poetter, Brendan Toohey, Ron Harvey, Lyn Griffiths
Primary Institution: Griffith University
Hypothesis
Is the GATA-4 gene variant S377G associated with migraine susceptibility?
Conclusion
The GATA-4 (S377G) mutation does not play a significant role in common migraine susceptibility.
Supporting Evidence
- The study involved a large case/control population of 550 individuals.
- No significant association was found between the GATA-4 polymorphism and migraine.
- The study was ethically approved and all participants provided consent.
Takeaway
The study looked at a gene that might be linked to migraines but found no connection.
Methodology
An association analysis was performed comparing 275 migraineurs to 275 matched controls.
Potential Biases
None reported.
Limitations
The study did not test for PFO or other heart disorders in participants.
Participant Demographics
275 unrelated Caucasian migraineurs and 275 matched control individuals.
Statistical Information
P-Value
0.66
Statistical Significance
p=0.66
Digital Object Identifier (DOI)
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