An Acetylenic Alkaloid from the Calcareous Sponge Leucetta sp.
2011
New Acetylenic Alkaloid from Leucetta Sponge
publication
Evidence: moderate
Author Information
Author(s): Hermawan Idam, Nicole J. de Voogd, Junichi Tanaka
Primary Institution: University of the Ryukyus
Hypothesis
A new acetylenic alkaloid was isolated from the sponge Leucetta sp.
Conclusion
The study identified a new cytotoxic acetylenic alkaloid from a marine sponge.
Supporting Evidence
- A new acetylenic alkaloid was isolated from the sponge Leucetta sp.
- The alkaloid showed cytotoxicity IC50 2.5 μg/mL against NBT-T2 cells.
- Compound 1 is the first example of polyacetylene with an alkaloidal functionality from a marine sponge.
Takeaway
Scientists found a new chemical from a sponge that can kill certain cells. This could help in making new medicines.
Methodology
The sponge was extracted with acetone, and the cytotoxicity of the alkaloid was tested on NBT-T2 cells.
Limitations
The original amount of the compound was small, limiting distribution.
Digital Object Identifier (DOI)
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