Identifying Cognitive Changes in Older Adults at Risk for Alzheimer's
Author Information
Author(s): Felix Cynthia, Kollasserry Felix Joy, Rebok George, Snitz Beth, Ferreira Pamela, Klunk William, Baker Suzanne, Pascoal Tharick
Primary Institution: University of Pittsburgh
Hypothesis
Sub-categorizing cognitively unimpaired older adults based on amyloid and tau pathologies can help in cognitive phenotyping using MoCA.
Conclusion
MoCA can effectively detect cognitive dysfunction in cognitively unimpaired older adults who are amyloid and tau positive.
Supporting Evidence
- The study involved 147 cognitively unimpaired older adults.
- MoCA total scores showed significant differences between groups based on amyloid and tau status.
- MK6240 demonstrated more sensitivity than Flortaucipir in detecting cognitive dysfunction.
Takeaway
Researchers are trying to figure out how to spot early signs of Alzheimer's in older people who seem fine, using a simple test called MoCA.
Methodology
The study involved 147 cognitively unimpaired older adults who were evaluated using PET imaging and the MoCA test.
Participant Demographics
Cognitively unimpaired older adults with a CDR global score of 0.
Statistical Information
P-Value
0.013, 0.049, 0.041, 0.033
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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