Childhood Wheezing Phenotypes and Adult Outcomes
Author Information
Author(s): Carra Sophie, Zhang Hongmei, Tanno Luciana Kase, Arshad Syed Hasan, Kurukulaaratchy Ramesh J.
Primary Institution: University Hospital Southampton
Hypothesis
Different childhood wheezing phenotypes have varying longitudinal outcomes at age 26.
Conclusion
Early-life factors influence adult outcomes for childhood wheezing phenotypes, affecting both the development of adult wheezing and remission of wheeze in childhood wheezers.
Supporting Evidence
- Childhood wheezing phenotypes showed different subsequent outcomes and associated risk factors.
- Adult wheeze developed in 17.8% of participants who did not wheeze at age 10.
- 56.1% of childhood wheezers had remission of wheeze by age 26.
Takeaway
Kids who wheeze can have different outcomes as adults, and things that happen early in life can affect whether they continue to wheeze or not.
Methodology
Participants were followed from birth through ages 1, 2, 4, 10, 18, and 26 years, with assessments of wheeze prevalence and phenotypic characteristics.
Potential Biases
Potential recall bias in early-life factors and the observational nature of the study.
Limitations
Lack of objective data on lung function in the first 4 years of life and a homogeneous population limit generalizability.
Participant Demographics
Participants were from the Isle of Wight Birth Cohort, primarily white and of similar socioeconomic status.
Statistical Information
P-Value
p<0.0005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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