Cytokine Responses in Chicken Cells Infected with Campylobacter jejuni
Author Information
Author(s): Li Yi-Ping, Ingmer Hanne, Madsen Mogens, Bang Dang D
Primary Institution: Technical University of Denmark (DTU)
Hypothesis
How do Campylobacter jejuni strains from humans and chickens interact with chicken embryo intestinal cells?
Conclusion
C. jejuni strains from both human and chicken origins can invade chicken cells and trigger a pro-inflammatory response.
Supporting Evidence
- C. jejuni strains can invade chicken embryo intestinal cells.
- The bacteria stimulate a pro-inflammatory response in these cells.
- Virulence-associated genes of C. jejuni are expressed during the invasion process.
Takeaway
This study shows that bacteria from chickens and humans can invade chicken cells and make them react in a way that causes inflammation.
Methodology
The study used primary chicken embryo intestinal cells to assess the invasion and cytokine response to C. jejuni strains.
Statistical Information
P-Value
p = 0.042, p = 0.012, p = 0.046, p = 0.025, p = 0.019, p = 0.041, p = 0.020, p = 0.029
Statistical Significance
p ≤ 0.011
Digital Object Identifier (DOI)
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