Transport of Guanidino Compounds in the Brain
Author Information
Author(s): Tachikawa Masanori, Hosoya Ken-ichi
Primary Institution: Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
Hypothesis
The creatine transporter (CRT) at the blood-brain barrier (BBB) mediates the transport of creatine and guanidino compounds, influencing their levels in the brain.
Conclusion
Transport of guanidino compounds at the BBB and blood-cerebrospinal fluid barrier is crucial for maintaining their levels in the brain, and alterations in this transport may lead to neurological disorders.
Supporting Evidence
- Guanidino compounds are present in the brain and play roles in energy homeostasis.
- Transporters at the BBB and BCSFB are key for the distribution of guanidino compounds.
- Altered transport of guanidino compounds may lead to neurological disorders.
Takeaway
This study looks at how certain compounds important for brain function are moved in and out of the brain, which is important for understanding brain health and diseases.
Methodology
The study used various in vivo and in vitro methods to evaluate the transport of guanidino compounds across the BBB and BCSFB.
Potential Biases
Potential bias in the interpretation of existing studies and their methodologies.
Limitations
The review primarily discusses existing literature and may not include new experimental data.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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