Study of a Zinc-Gabapentin Complex
Author Information
Author(s): Elise J. C. de Vries, Caryn Gamble, Ahmed Shaikjee
Primary Institution: Molecular Science Institute, School of Chemistry, University of the Witwatersrand, Johannesburg, South Africa
Hypothesis
This study investigates the effect of the nitrate counterion on the nature of the metal gabapentin complex formed.
Conclusion
The study reveals that the zinc ions in the complex have different coordination environments and that the conformation of the gabapentin molecule is stabilized by hydrogen bonds.
Supporting Evidence
- The asymmetric unit contains two disordered nitrate ions and half a complex molecule.
- The two zinc ions have different coordination environments: one is slightly distorted octahedral and the other is trigonal–pyramidal.
- The conformation of the gabapentin molecule is defined by the formation of two intramolecular hydrogen bonds.
Takeaway
The researchers looked at how a specific metal compound interacts with a drug called gabapentin, finding that the structure of the compound is influenced by how the metal and drug bond together.
Methodology
The complex was obtained by reflux solution crystallization of gabapentin and a metal salt in distilled water.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website