Effects of Salvia leriifolia Extracts on Muscle Injury in Rats
Author Information
Author(s): Hosseinzadeh Hossein, Hosseini Azar, Nassiri-Asl Marjan, Sadeghnia Hamid-Reza
Primary Institution: Mashhad University of Medical Sciences
Hypothesis
The study evaluates the protective effects of Salvia leriifolia extracts on ischemia-reperfusion injury in rat skeletal muscle.
Conclusion
Salvia leriifolia root extracts have protective effects against oxidative damage in muscle tissue caused by ischemia-reperfusion.
Supporting Evidence
- The extracts increased the average peak-to-peak amplitude of EMG signals during ischemia-reperfusion.
- Total sulfhydryl contents and antioxidant capacity were elevated in muscle flap after extract administration.
- MDA levels, an indicator of oxidative stress, significantly decreased in the test groups.
Takeaway
This study found that a plant called Salvia leriifolia can help protect muscles from damage when blood flow is cut off and then restored.
Methodology
The study used Wistar male rats, inducing ischemia through free-flap surgery, and administered different doses of Salvia leriifolia extracts before reperfusion.
Participant Demographics
Wistar male rats, weighing 200–230 g.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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