Ceftazidime Infusion in Critically Ill Patients
Author Information
Author(s): Mariat Christophe, Venet Christophe, Jehl François, Mwewa Sandrine, Lazarevic Vesna, Diconne Eric, Fonsale Nathalie, Carricajo Anne, Guyomarc'h Stéphane, Vermesch Régine, Aubert Gérald, Bidault Roselyne, Bertrand Jean-Claude, Zeni Fabrice
Primary Institution: Service de Néphrologie, Hôpital Nord, CHU de Saint-Etienne, Saint-Etienne, France
Hypothesis
What is the optimal dosage of ceftazidime for critically ill patients undergoing continuous venovenous haemodiafiltration?
Conclusion
A dosing regimen of 3 g/day ceftazidime, following a 2 g loading dose, results in effective serum concentrations for treating infections in critically ill patients undergoing CVVHDF.
Supporting Evidence
- Ceftazidime concentrations were maintained above 30 mg/l for most patients during the study.
- The mean elimination half-life of ceftazidime was found to be 4 ± 1 hours.
- The mean steady-state ceftazidime concentration was 33.5 mg/l, which is effective against susceptible pathogens.
Takeaway
Doctors found that giving a specific amount of ceftazidime medicine continuously helps sick patients with kidney problems get better without too much medicine in their bodies.
Methodology
Seven critically ill patients received a 2 g loading dose of ceftazidime followed by a 3 g/day continuous infusion for 72 hours during CVVHDF.
Limitations
The study had a small sample size and was conducted in a single center.
Participant Demographics
All participants were male, aged over 18, with suspected bacterial infections and acute renal failure.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website