Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer
2001
CYP1B1 Over-Expression in Ovarian Cancer
publication
Evidence: moderate
Author Information
Author(s): McFadyen M C E, Cruickshank M E, Miller I D, McLeod H L, Melvin W T, Haites N E, Parkin D, Murray G I
Primary Institution: University of Aberdeen
Hypothesis
The presence of CYP1B1 may influence the response of ovarian cancer to anti-cancer drugs.
Conclusion
CYP1B1 is over-expressed in 92% of ovarian cancers, indicating its potential role in cancer treatment.
Supporting Evidence
- CYP1B1 was found in 92% of ovarian cancer cases studied.
- There was a strong correlation between CYP1B1 expression in primary and metastatic ovarian cancer.
- No detectable CYP1B1 was found in normal ovarian tissue.
Takeaway
This study found that a protein called CYP1B1 is found a lot in ovarian cancer, which might help doctors understand how to treat it better.
Methodology
A comprehensive immunohistochemical investigation was conducted to assess CYP1B1 presence in ovarian cancer.
Statistical Information
P-Value
0.005
Statistical Significance
p=0.005
Digital Object Identifier (DOI)
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