CD39+ Regulatory T Cells and Th17 Cells in Lung Cancer
Author Information
Author(s): Ye Zhi-Jian, Zhou Qiong, Zhang Jian-Chu, Li Xiao, Wu Cong, Qin Shou-Ming, Xin Jian-Bao, Shi Huan-Zhong
Primary Institution: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China
Hypothesis
CD39+ Tregs suppress the generation and differentiation of Th17 cells in malignant pleural effusion via a LAP-dependent mechanism.
Conclusion
CD39+Tregs inhibit the generation and differentiation of Th17 cells in malignant pleural effusion.
Supporting Evidence
- Both CD39+ Tregs and Th17 cells were increased in malignant pleural effusion compared to blood.
- The numbers of CD39+ Tregs were negatively correlated with those of Th17 cells.
- High levels of IL-1β, IL-6, and TGF-β1 were observed in malignant pleural effusion.
Takeaway
In patients with lung cancer, a type of immune cell called CD39+ Tregs can stop another type of immune cell, Th17 cells, from growing and working.
Methodology
Flow cytometry was used to analyze CD39+ Tregs and Th17 cells in pleural effusion and blood samples from lung cancer patients.
Participant Demographics
Patients aged 31 to 76 years with newly diagnosed lung cancer and malignant pleural effusion.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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