Urine 1-Hydroxy Pyrene Glucuronide Levels and Cancer Risk in Brazil
Author Information
Author(s): Fagundes Renato B, Abnet Christian C, Strickland Paul T, Kamangar Farin, Roth Mark J, Taylor Philip R, Dawsey Sanford M
Primary Institution: Universidade Federal de Santa Maria
Hypothesis
Is there a link between tobacco smoke exposure, maté consumption, and urine 1-hydroxy pyrene glucuronide levels in healthy adults from southern Brazil?
Conclusion
Tobacco smoke and maté both contribute to high levels of benzo[a]pyrene exposure in the people of southern Brazil.
Supporting Evidence
- The median urine 1-OHPG concentration was 2.09 pmol/mL.
- Tobacco smoke exposure and maté drinking were significantly associated with higher urine 1-OHPG concentrations.
- The study included a diverse group of participants from Rio Grande do Sul.
Takeaway
People who smoke or drink maté have higher levels of a chemical in their urine that can be linked to cancer.
Methodology
The study involved 200 healthy adults who provided urine samples and completed a questionnaire about their smoking and drinking habits.
Potential Biases
Potential confounding factors related to dietary habits and environmental exposures were not fully controlled.
Limitations
The study did not measure the temperature at which maté was consumed, which could affect the results.
Participant Demographics
200 healthy adults, half smokers and half non-smokers, evenly divided by sex.
Statistical Information
P-Value
0.0004
Confidence Interval
95% CI for age quartile 3: 0.082, 0.72
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website