Nicotinamide Protects against Ethanol-Induced Apoptotic Neurodegeneration in the Developing Mouse Brain
2006
Nicotinamide Protects Developing Mouse Brain from Alcohol Damage
publication
Author Information
Author(s): D Herrera, A Ieraci
Primary Institution: Weill Medical College of Cornell University
Hypothesis
Can nicotinamide prevent ethanol-induced neuronal cell death in the developing brain?
Conclusion
Nicotinamide can prevent neuronal cell death by acting at different and probably complementary molecular levels.
Supporting Evidence
- Nicotinamide prevents the activation of JNK, which is involved in neuronal death.
- Nicotinamide increases the activation of Akt, which protects against cell death.
- Nicotinamide prevents the release of cytochrome-c, a key factor in cell death.
- Nicotinamide increases NAD levels in the brain, which helps maintain energy supply.
Takeaway
Nicotinamide helps protect young brains from damage caused by alcohol by working in several ways to keep brain cells alive.
Digital Object Identifier (DOI)
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