Role of lipoxygenase products in the effects of angiotensin II in the isolated aorta and perfused heart of the rat
Author Information
Author(s): J. P. M. Dam, CA E. van den Worm, W. Vleeming, M. J. Post, A. J. Porsius, J. Wemer
Primary Institution: Utrecht University, Faculty of Pharmacy
Hypothesis
Do arachidonate metabolites play a role in the vascular effects of angiotensin II in rats?
Conclusion
Arachidonate metabolites mediate part of the angiotensin II-induced decreases in coronary flow in the isolated perfused rat heart.
Supporting Evidence
- NDGA significantly reduced the maximal constriction to angiotensin II.
- Dexamethasone pretreatment suppressed the decreases in coronary flow.
- Losartan reduced angiotensin II-induced decreases in coronary flow.
- 5-1ipoxygenase products are likely mediators of the effects of angiotensin II.
- Indomethacin had no effect on angiotensin II-induced contractions.
- AA 861 did not significantly reduce responses to angiotensin II.
Takeaway
This study found that certain substances in the body help control blood flow when a hormone called angiotensin II is present, which is important for heart health.
Methodology
The study used isolated Langendorff perfused rat hearts and aortic rings to test the effects of various drugs on coronary flow and contractions.
Participant Demographics
196 male Wistar rats, weighing 180-260g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website