Mito-Modulatory Medication Use and Muscle Energy in Older Adults
Author Information
Author(s): Phang, Bergstrom, Atayee, Hart, Cawthon, Cummings, Molina
Primary Institution: University of California, San Diego
Hypothesis
Mito-modulatory medication use would be associated with lower skeletal muscle ex vivo (MAX ETS) and in vivo (ATPMax) bioenergetic measures.
Conclusion
Mito-modulatory medication use is related to lower skeletal muscle bioenergetics in older men but not women.
Supporting Evidence
- MAX ETS was lower in mito-modulatory medication users compared to non-users for men.
- ATP-Max was lower in mito-modulatory medication users compared to non-users for men.
- Adjustments for confounders affected some associations but not all.
Takeaway
Some medications can affect how our muscles use energy, and this seems to be more of a problem for older men than women.
Methodology
Data from the Study of Muscle, Mobility and Aging (SOMMA) was used to assess the relationship between mito-modulatory medication use and skeletal muscle bioenergetics.
Limitations
Adjustments for potential confounders attenuated some associations, indicating that results may vary with different factors.
Participant Demographics
Older adults, with a focus on differences between men and women.
Statistical Information
P-Value
p=0.0021 for MAX ETS in men; p=0.0004 for ATP-Max in men.
Confidence Interval
[77.7-87.0] for MAX ETS; [0.50-0.57] for ATP-Max.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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