Improving Follow-Up for Cervical Dysplasia with HPV Testing
Author Information
Author(s): Nobbenhuis M A E, Meijer C J L M, Brule A J C van den, Rozendaal L, Voorhorst F J, Risse E K J, Verheijen R H M, Helmerhorst T J M
Primary Institution: Department of Obstetrics and Gynaecology, University Hospital Rotterdam
Hypothesis
Does high-risk HPV testing improve follow-up guidelines after treatment for cervical intraepithelial neoplasia?
Conclusion
High-risk HPV testing is more predictive of post-treatment cervical intraepithelial neoplasia than cervical cytology alone.
Supporting Evidence
- A positive high-risk HPV test 6 months after treatment was more predictive for post-treatment CIN 2/3 than abnormal cervical cytology.
- The sensitivity of high-risk HPV testing was 90%, compared to 62% for cervical cytology.
- The negative predictive value of a high-risk HPV negative, normal smear at 6 months was 99%.
Takeaway
This study found that testing for a virus called HPV after treatment for cervical changes can help doctors better check if the treatment worked.
Methodology
184 women treated for CIN 2 or 3 were monitored with cervical cytology and high-risk HPV testing at multiple time points after treatment.
Participant Demographics
Women treated for cervical intraepithelial neoplasia (CIN) 2 or 3.
Digital Object Identifier (DOI)
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