Increased Hip Fracture Risk in Men with Type 2 Diabetes
Author Information
Author(s): Ding Huiru, Wang Hongxia, Liu Guanghui, Wang Yu, Han Dongxu, Zhang Xiaoya, Song Lige
Primary Institution: Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
Hypothesis
Is there a correlation between urine albumin-to-creatinine ratio (ACR) and hip fracture risk in patients with type 2 diabetes mellitus?
Conclusion
Higher urine ACR levels and longer diabetes duration are linked to increased hip fracture risk in older men with type 2 diabetes.
Supporting Evidence
- Urinary ACR levels were positively associated with hip fracture risk in older men.
- Duration of type 2 diabetes was also positively correlated with hip fracture risk.
- Femoral neck BMD was negatively correlated with hip fracture risk.
Takeaway
Men with type 2 diabetes who have higher levels of a specific protein in their urine are more likely to break their hips as they get older.
Methodology
This cross-sectional study included 435 individuals with type 2 diabetes, measuring urine ACR and assessing hip fracture risk through multiple regression analysis.
Potential Biases
Potential bias due to incomplete medical history and the exclusion of brittle fractures.
Limitations
The study had a limited number of cases, especially with macroalbuminuria, and relied on a single measurement of urine ACR.
Participant Demographics
The study included 219 postmenopausal women and 216 older men, aged over 60 years.
Statistical Information
P-Value
0.018 for diabetes duration, 0.044 for ACR
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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