Blood Pressure and Kidney Function in Pre-Dialysis Patients
Author Information
Author(s): Moniek CM de Goeij, Nora Voormolen, Nynke Halbesma, Dinanda J de Jager, Elisabeth W Boeschoten, Yvo WJ Sijpkens, Friedo W Dekker, Diana C Grootendorst
Primary Institution: Leiden University Medical Center
Hypothesis
Does high blood pressure accelerate renal function decline in patients with advanced chronic kidney disease?
Conclusion
High blood pressure, especially systolic blood pressure, is linked to a faster decline in kidney function and an earlier start of renal replacement therapy in pre-dialysis patients.
Supporting Evidence
- Every 10 mmHg increase in systolic blood pressure led to a 0.04 ml/min/1.73 m2/month faster decline in renal function.
- Patients with systolic blood pressure above 130 mmHg had a 2.08 times higher risk of starting renal replacement therapy.
- 89% of patients did not reach the blood pressure target goal of < 130/80 mmHg.
Takeaway
If you have high blood pressure, your kidneys might not work as well, and you could need dialysis sooner.
Methodology
The study followed 547 pre-dialysis patients from eight Dutch hospitals, measuring blood pressure and renal function over time.
Potential Biases
Potential residual confounding due to unmeasured variables affecting kidney function.
Limitations
The study only measured blood pressure once at the start of pre-dialysis care, which may not reflect changes over time.
Participant Demographics
57% men, median age 63 years, predominantly Caucasian.
Statistical Information
P-Value
0.04
Confidence Interval
(0.02;0.07)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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