ArrayIDer: A Tool for Re-annotating DNA Microarrays
Author Information
Author(s): Bart HJ van den Berg, Jay H Konieczka, Fiona M McCarthy, Shane C Burgess
Primary Institution: Mississippi State University
Hypothesis
Can ArrayIDer improve the structural annotation of microarrays for non-traditional biomedical model organisms?
Conclusion
ArrayIDer allows rapid automated structural re-annotation of entire arrays and provides multiple accession types for use in subsequent functional analysis.
Supporting Evidence
- ArrayIDer structurally re-annotated 55% of the entire chicken microarray.
- The tool decreased non-chicken functional annotations by 2 fold.
- ArrayIDer identified 290 pseudogenes, correcting 66 previously misannotated genes.
Takeaway
ArrayIDer is a computer program that helps scientists quickly update the information about genes on DNA microarrays, making it easier to understand what those genes do.
Methodology
ArrayIDer retrieves accession mapping files from public databases based on EST clone names and generates database accessions for entire microarrays.
Limitations
The tool may not cover all species and relies on the availability of updated databases.
Digital Object Identifier (DOI)
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