Anti-Leukemic Effects of Typhonium flagelliforme Extract
Author Information
Author(s): Mohan Syam, Bustamam Ahmad, Ibrahim Siddig, Al-Zubairi Adel S., Aspollah Mohammed, Abdullah Rasedee, Elhassan Manal Mohamed
Primary Institution: University Putra Malaysia
Hypothesis
The study aimed to evaluate the in vitro anti-leukemic activity of a specific extract from Typhonium flagelliforme on human leukemia cells.
Conclusion
The extract from Typhonium flagelliforme demonstrated significant anti-leukemic effects by inducing apoptosis in leukemia cells.
Supporting Evidence
- 7 out of 12 fractions showed significant cytotoxicity against CEMss cells.
- DCM/F7 exhibited an IC50 value of 3 μg/ml, indicating strong anti-leukemic activity.
- Apoptosis was confirmed through various assays including TUNEL and morphological observations.
Takeaway
This study found that a plant extract can help kill cancer cells by making them die in a special way called apoptosis.
Methodology
The study involved extracting and fractionating the plant, testing its cytotoxicity on leukemia cells, and assessing apoptosis through various microscopic techniques.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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