Small Oscillatory Accelerations Increase Bone Activity
Author Information
Author(s): Garman Russell, Rubin Clinton, Judex Stefan
Primary Institution: Department of Biomedical Engineering, State University of New York at Stony Brook
Hypothesis
The physical acceleration of a cell may present a signal which can transmit physical challenges to a receptive cell population in an efficient and safe manner.
Conclusion
Applying small oscillatory accelerations without weight bearing significantly enhances bone formation and improves bone morphology.
Supporting Evidence
- Bone formation rates increased by 70% in the tibiae subjected to oscillatory accelerations.
- Bone volume fraction improved by 17% and connectivity density by 33% in accelerated bones.
- Trabecular spacing decreased by 6% and structural model index by 11% in the accelerated group.
Takeaway
If you shake a bone gently, it can grow stronger without hurting it, just like how plants grow better with a little wind.
Methodology
The study involved 27 female mice subjected to oscillatory accelerations on one tibia while the other served as a control.
Potential Biases
Potential bias due to the specific genetic background of the mouse model used.
Limitations
The study was limited to a specific mouse strain and the effects on cortical bone were not significant.
Participant Demographics
Adult female BALB/cByJ mice, 19 weeks old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website