Efficient Synthesis of Novel Pyrano and Furopyrano Pyrimidines
Author Information
Author(s): Prajapati Dipak, Gohain Mukut
Primary Institution: Department of Medicinal Chemistry, Regional Research Laboratory, Jorhat, Assam, India
Hypothesis
Can indium(III) chloride catalyze an efficient synthesis of fused pyrimidine derivatives via a multi-component domino reaction?
Conclusion
The study demonstrates an efficient method for synthesizing novel fused pyrimidines with high yields and selectivity.
Supporting Evidence
- Various novel pyrano and furopyrano pyrimidines were synthesized in 80–99% yields.
- The reaction also proceeds in aqueous media without using any catalyst, but the yield is comparatively less (65–70%).
- The method provides excellent yields of products with selectivity.
Takeaway
This study shows a new way to make special chemical compounds that can help in medicine, using a simple method that works really well.
Methodology
The synthesis involved a multicomponent domino reaction of 1,3-dimethyl barbituric acid with an aromatic aldehyde and ethyl vinyl ether/2,3-dihydrofuran in the presence of indium(III) chloride.
Limitations
The reaction did not proceed with aliphatic or heterocyclic aldehydes.
Digital Object Identifier (DOI)
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