Prognostic Score in Node Negative Breast Cancer
Author Information
Author(s): B. Chevallier, V. Mosseri, J.P. Dauce, P. Bastit, J.P. Julien, B. Asselain
Primary Institution: Centre H. Becquerel, Rouen, France; Institut Curie, Paris, France
Hypothesis
The study aims to identify factors indicating a bad prognosis in node negative breast cancer and to construct a prognostic score based on these factors.
Conclusion
The study developed a prognostic score that effectively categorizes patients into groups with significantly different survival outcomes.
Supporting Evidence
- Overall survival at 5 years was 88% and disease-free survival was 78%.
- Patients aged <37 years had a significantly worse prognosis.
- Prognostic scores divided patients into three groups with significantly different outcomes.
Takeaway
This study looked at women with breast cancer that hadn't spread to lymph nodes and found ways to predict who might have a worse outcome.
Methodology
The study analyzed data from 379 patients treated for unilateral, non-metastatic breast cancer, measuring various prognostic factors and survival rates.
Potential Biases
There may be risks of bias due to the retrospective nature of the study and the exclusion of certain patient groups.
Limitations
The study's sample size was relatively small, limiting the validation of the prognostic scores.
Participant Demographics
The average age of participants was 56 years, with a range from 29 to 86 years.
Statistical Information
P-Value
p<0.001 for tumour size, p<0.01 for histological grading, p<0.05 for age and progesterone receptor levels.
Statistical Significance
p<0.0001
Want to read the original?
Access the complete publication on the publisher's website