The Role of OLR1 in Obesity, Lipid Disorders, and Cancer
Author Information
Author(s): Khaidakov Magomed, Mitra Sona, Kang Bum-Yong, Wang Xianwei, Kadlubar Susan, Novelli Giuseppe, Raj Vinay, Winters Maria, Carter Weleetka C., Mehta Jawahar L.
Primary Institution: University of Arkansas for Medical Sciences
Hypothesis
OLR1 may act as a link between dyslipidemia and cancer.
Conclusion
OLR1 may function as an oncogene by activating NF-kB target genes that promote proliferation, migration, and inhibit apoptosis.
Supporting Evidence
- OLR1 deletion in mice resulted in reduced expression of NF-kB target genes involved in cancer.
- Over-expression of OLR1 in cancer cells increased their migration.
- Inhibition of OLR1 led to reduced tumor growth in vivo.
Takeaway
This study suggests that a protein called OLR1 might help cancer cells grow by affecting how they respond to fat in the body.
Methodology
The study involved microarray analysis of gene expression in OLR1 knockout and wild-type mice, as well as experiments on breast cancer cell lines.
Statistical Information
P-Value
p<0.00003
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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