Bacopa monniera Helps Memory in Mice
Author Information
Author(s): Manish Kumar Saraf, Sudesh Prabhakar, Krishan Lal Khanduja, Akshay Anand
Primary Institution: Post Graduate Institute of Medical Education and Research, Chandigarh, India
Hypothesis
Can Bacopa monniera reverse scopolamine-induced impairment of spatial memory in mice?
Conclusion
Bacopa monniera extract can reverse both anterograde and retrograde amnesia induced by scopolamine in mice.
Supporting Evidence
- Bacopa monniera extract was able to reverse both anterograde and retrograde amnesia.
- Scopolamine significantly impaired memory acquisition and retrieval.
- Bacopa monniera showed better antiamnesic effects with lower doses of scopolamine.
Takeaway
This study shows that a plant called Bacopa monniera can help mice remember things better when they are given a memory-impairing drug.
Methodology
Mice were tested using the Morris water maze to evaluate memory acquisition and retrieval after treatment with Bacopa monniera and scopolamine.
Limitations
The study did not find significant effects of Bacopa monniera on normal memory acquisition and retrieval.
Participant Demographics
Swiss albino male mice, aged 3-5 months, weighing 25-35g.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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