First case report of primary cardiac leiomyosarcoma with partial rhabdomyoblastic differentiation
Author Information
Author(s): Okubo Yoichiro, Shibuya Kazutoshi, Namiki Atsushi, Takamura Kazuhisa, Kameda Noriaki, Nemoto Tetsuo, Mitsuda Aki, Wakayama Megumi, Shinozaki Minoru, Hiruta Nobuyuki, Kitahara Kanako, Ishiwatari Takao, Yamazaki Junichi
Primary Institution: Toho University School of Medicine
Hypothesis
Rhabdomyoblastic differentiation in leiomyosarcoma might be generated not only by de novo generation from mesenchymal cells.
Conclusion
This is the first report of primary cardiac leiomyosarcoma with partial rhabdomyoblastic differentiation, which indicated aggressive growth and led to the patient's death despite early diagnosis and surgical removal.
Supporting Evidence
- Leiomyosarcoma is an extremely rare primary cardiac tumor.
- The tumor showed aggressive growth and led to the patient's death due to multiple lung metastases.
- Histopathological evaluation indicated a myxoid type of leiomyosarcoma.
- Immunohistochemical findings suggested rhabdomyoblastic differentiation in the tumor.
Takeaway
A woman had a rare heart tumor that was a type of cancer called leiomyosarcoma, which showed some features of muscle cell development. Unfortunately, she passed away after surgery.
Methodology
The tumor was surgically removed and evaluated histopathologically and immunohistochemically.
Limitations
The patient's renal dysfunction prevented adjuvant chemotherapy.
Participant Demographics
A 69-year-old woman with a history of hypertension and polycystic kidney disease.
Digital Object Identifier (DOI)
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