Diastolic Flow and Heart Failure
Author Information
Author(s): Eriksson Jonatan, Dyverfeldt Petter, Engvall Jan, Bolger Ann F, Ebbers Tino, Carlhäll Carl Johan
Primary Institution: Center for Medical Image Science and Visualization (CMIV), Linköping University
Hypothesis
We hypothesized that diastolic flow in the normal LV would prepare an effective systolic ejection by virtue of increased end-diastolic kinetic energy of the ejected blood.
Conclusion
Diastolic flow is quantitatively altered in dilated and hypocontractile LVs, which may contribute to the inefficiency of the failing LV.
Supporting Evidence
- The LV ED diameter was larger and LV ejection fraction was smaller in DCM compared to healthy subjects.
- At end-diastole, the KE of the non-ejecting blood was higher in DCM compared to healthy subjects.
- There was no difference in the KE of the ejecting blood between the groups.
Takeaway
In a healthy heart, the way blood flows before it is pumped out is important, but this flow is messed up in hearts that are not working well.
Methodology
4D phase-contrast CMR velocity data and morphological images were acquired from patients and healthy subjects to analyze blood flow patterns.
Participant Demographics
8 dilated cardiomyopathy patients (4 female, mean age 51) and 12 healthy subjects (5 female, mean age 44).
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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