Oligosaccharides Improve Insulin Sensitivity
Author Information
Author(s): Hao Cui, Hao Jiejie, Wang Wei, Han Zhangrun, Li Guangsheng, Zhang Lijuan, Zhao Xia, Yu Guangli
Primary Institution: Ocean University of China
Hypothesis
Can marine oligosaccharides oligomannuronate and its chromium (III) complexes enhance insulin sensitivity in C2C12 skeletal muscle cells?
Conclusion
Oligomannuronate and its chromium (III) complexes improved insulin sensitivity in C2C12 skeletal muscle cells and could serve as a potential treatment for type 2 diabetes.
Supporting Evidence
- Oligomannuronate and its chromium (III) complexes enhanced insulin-stimulated glucose uptake in muscle cells.
- The treatment increased the expression of glucose transporter 4 (GLUT4) and insulin receptor (IR) mRNA.
- Oligosaccharides activated both the insulin signaling pathway and AMPK pathways.
- The effects of marine oligosaccharides were comparable to the anti-diabetic drug metformin.
- Oligosaccharides showed less toxicity than metformin.
Takeaway
This study found that certain sugars from seaweed can help muscles use insulin better, which is important for people with diabetes.
Methodology
The study involved treating C2C12 skeletal muscle cells with oligomannuronate and its chromium (III) complexes and measuring glucose uptake and mRNA expression of insulin receptors.
Limitations
The study was conducted in vitro, and further research is needed to confirm the effects in vivo.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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