Silencing of GM3 synthase suppresses lung metastasis of murine breast cancer cells
2008
Silencing GM3 Synthase Reduces Lung Metastasis in Breast Cancer
Sample size: 6
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Gu Yuchao, Zhang Junhua, Mi Wenyi, Yang Jing, Han Feng, Lu Xinzhi, Yu Wengong
Primary Institution: Ocean University of China
Hypothesis
Does silencing GM3 synthase affect breast cancer metastasis?
Conclusion
Silencing GM3 synthase suppresses lung metastasis in murine breast cancer cells by inhibiting the PI3K/Akt pathway.
Supporting Evidence
- GM3 synthase silencing in 4T1 cells significantly inhibited cell migration and invasion.
- Over-expression of GM3 synthase in 67NR cells significantly induced cell migration.
- Silencing GM3 synthase reduced the number of metastatic nodules in the lungs of tumor-bearing mice.
Takeaway
When scientists turned off a gene called GM3 synthase in breast cancer cells, the cancer spread less to the lungs. This might help doctors find new ways to treat breast cancer.
Methodology
The study involved silencing GM3 synthase in breast cancer cell lines and assessing their migration, invasion, and metastasis in vitro and in vivo.
Participant Demographics
Female BALB/c mice, aged 8 to 10 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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