Klotho Levels and Chronic Kidney Disease in Adults with Metabolic Syndrome
Author Information
Author(s): Lin Xiaobin, Yang Lin
Primary Institution: National Clinical Research Center for Metabolic Diseases, Central South University, China
Hypothesis
This study explores the relationship between serum Klotho levels and the odds of chronic kidney disease in middle-aged and older populations with metabolic syndrome.
Conclusion
There is a nonlinear L-shaped relationship between serum Klotho levels and the risk of chronic kidney disease, with the lowest prevalence observed at Klotho concentrations between 9.63 and 9.94 pg/mL.
Supporting Evidence
- An inflection point of 9.88 pg/mL was noted for Klotho levels.
- Higher Klotho levels were associated with a decreased risk of CKD.
- The study included a large sample size representative of the U.S. population.
- Statistical analyses were conducted using complex survey design methods.
Takeaway
This study found that having the right amount of a protein called Klotho can help keep your kidneys healthy, especially for older people with metabolic syndrome.
Methodology
This cross-sectional study analyzed data from 4870 adults aged 40–79 years from the NHANES survey, using logistic regression models to assess the correlation between Klotho and CKD.
Potential Biases
Potential unmeasured confounding variables could impact the relationship between Klotho and CKD.
Limitations
The cross-sectional design limits causal inference, and serum Klotho was measured only once, which may not capture dynamic changes.
Participant Demographics
Participants were middle-aged and older adults (ages 40-79) with metabolic syndrome, with 51.6% being female and an average age of 57.7 years.
Statistical Information
P-Value
0.006
Confidence Interval
95% CI, 0.53–0.79
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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