Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium

2009

Genetic Risk Factors for Ovarian Cancer

Sample size: 5460 publication 10 minutes Evidence: moderate

Author Information

Author(s): C L Pearce, A M Near, D J Van Den Berg, S J Ramus, A Gentry-Maharaj, U Menon, S A Gayther, A R Anderson, C K Edlund, A H Wu, X Chen, J Beesley, P M Webb, S K Holt, C Chen, J A Doherty, M A Rossing, A S Whittemore, V McGuire, R A DiCioccio, M T Goodman, G Lurie, M E Carney, L R Wilkens, B R Ness, K B Moysich, R Edwards, E Jennison, S K Kjaer, E Hogdall, C K Hogdall, E L Goode, T A Sellers, R A Vierkant, J C Cunningham, J M Schildkraut, A Berchuck, P G Moorman, E S Iversen, D W Cramer, K L Terry, A F Vitonis, L Titus-Ernstoff, H Song, P D P Pharoah, A B Spurdle, H Anton-Culver, A Ziogas, W Brewster, V Galitovskiy, G Chenevix-Trench

Primary Institution: Ovarian Cancer Association Consortium

Hypothesis

Is there a genetic susceptibility to ovarian cancer?

Conclusion

The study identified a possible association between the SNP rs2740574 in the CYP3A4 gene and an increased risk of ovarian cancer.

Supporting Evidence

Three SNPs showed evidence of association with ovarian cancer.
The CYP3A4 variant rs2740574 was associated with a 2.8-fold increased risk.
Findings were consistent across racial/ethnic groups.
Additional follow-up studies are warranted.

Takeaway

Scientists looked at genes to see if they can help explain why some people get ovarian cancer. They found one gene that might be linked to a higher risk.