Impact of Reduced Dose Schedule of PCV10 on Pneumococcal Carriage in Vietnam
Author Information
Author(s): Yoshida Lay-Myint M.B.,B.S., Ph.D., Toizumi Michiko M.D., Ph.D., Nguyen Hien Anh Thi M.Sc., Quilty Billy J Ph.D., Lien Le Thuy M.Sc., Hoang Le Huy PhD., Iwasaki Chihiro M.D., Takegata Mizuki Ph.D., Kitamura Noriko M.D., Ph.D., Nation Monica L M.Epi., Hinds Jason Ph.D., van Zandvoort Kevin M.Sc., Ortika Belinda D M.Sc., Dunne Eileen M Ph.D., Satzke Catherine Ph.D., Thai Hung Do M.D., Ph.D., Mulholland Kim M.B.,B.S., M.D., Flasche Stefan Ph.D., Anh Dang Duc Ph.D.
Primary Institution: Nagasaki University
Hypothesis
Is a single priming and booster dose (1p+1) non-inferior to three alternative dose schedules in sustaining control of PCV10 type carriage?
Conclusion
The 1p+1 reduced dosing schedule of PCV10 was not inferior to alternative vaccine dosing schedules in protection against VT carriage in infants and toddlers.
Supporting Evidence
- The study included 3124 children across four different dosing schedules.
- The 1p+1 schedule was found to be non-inferior to both 2p+1 and 3p+0 schedules.
- No severe adverse effects associated with the vaccine were reported.
Takeaway
This study shows that giving fewer doses of a pneumonia vaccine can still protect kids just as well as giving more doses.
Methodology
A cluster randomized non-inferiority trial was conducted with four intervention arms comparing different dosing schedules of PCV10.
Potential Biases
Some inter-cluster contamination may have occurred, potentially obscuring differences in vaccine effects.
Limitations
The study was affected by COVID-19, which reduced pneumococcal carriage prevalence and may have impacted the ability to detect differences between groups.
Participant Demographics
About 55% of participants were male, with less than 2% having underlying medical conditions.
Statistical Information
P-Value
0.3
Confidence Interval
95% CI: −1.6, 2.2
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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