The Role of NF-κB in PPARα-Mediated Liver Cancer Development
Author Information
Author(s): Howard P. Glauert, Karen Calfee-Mason, Yixin Li, Vani Nilakantan, Michelle L. Twaroski, Job Tharappel, Brett T. Spear
Primary Institution: University of Kentucky
Hypothesis
The activation of NF-κB by peroxisome proliferators in the liver is mediated by oxidative stress.
Conclusion
The activation of NF-κB is necessary for the tumor-promoting activity of peroxisome proliferators in the liver.
Supporting Evidence
- Peroxisome proliferators activate NF-κB in the livers of rats and mice.
- Activation of NF-κB is necessary for the promotion of liver tumors by peroxisome proliferators.
- Oxidative stress is a key mechanism in the activation of NF-κB by peroxisome proliferators.
Takeaway
Certain chemicals can cause liver cancer by activating a protein called NF-κB, which is influenced by stress in the liver cells.
Methodology
The review discusses various studies examining the activation of NF-κB by peroxisome proliferators in rats and mice, including in vitro and in vivo experiments.
Limitations
The review primarily focuses on animal studies, which may not fully translate to human responses.
Digital Object Identifier (DOI)
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