Cardiovascular Disease and Breast Cancer Stage at Diagnosis
Author Information
Author(s): Angelov Ivan BS, Haas Allen M. MS, Brock Elizabeth BS, Luo Lingfeng PhD, Zhao Jing PhD, Smith Benjamin D. MD, Giordano Sharon H. MD, Leeper Nicholas J. MD, Nead Kevin T. MD MPhil
Primary Institution: University of Texas MD Anderson Cancer Center
Hypothesis
Are individuals with advanced breast cancer at diagnosis more likely to have prevalent cardiovascular disease?
Conclusion
Individuals with more advanced breast cancer at diagnosis were more likely to have prevalent cardiovascular disease.
Supporting Evidence
- Patients with more advanced breast cancer at diagnosis had a statistically significant 10% increased odds of prevalent cardiovascular disease.
- The association was observed among hormone receptor–positive breast cancer but not hormone receptor–negative.
- Future studies are needed to confirm these findings and investigate interventions to improve patient outcomes.
Takeaway
This study found that people with heart problems might have more advanced breast cancer when they are diagnosed.
Methodology
This was a population-based case-control study using data from the Surveillance, Epidemiology, and End Results–Medicare linked databases.
Potential Biases
Potential for misclassification of cardiovascular disease and inability to control for some confounding factors, including smoking.
Limitations
The study is observational and does not demonstrate causality, and it may be susceptible to residual bias and confounding.
Participant Demographics
The cohort included 19,292 individuals, median age 73 years, with 8.7% Black and 86.5% White participants.
Statistical Information
P-Value
0.007
Confidence Interval
1.03-1.17
Statistical Significance
p=0.007
Digital Object Identifier (DOI)
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