Using Leukocyte-Platelet Rich Fibrin with Metronidazole for Periodontitis Treatment
Author Information
Author(s): Omar Yasmeen K., Rashidy Mohy A. El, Ahmed Ghada B., Aboulela Aliaa G.
Primary Institution: Alexandria University
Hypothesis
The study aimed to evaluate the efficacy of L-PRF as a locally sustained released device for metronidazole antimicrobial in treating moderate periodontitis.
Conclusion
Both treatment methods using L-PRF, with or without metronidazole, were effective in treating moderate periodontitis, but the combination showed better results.
Supporting Evidence
- Both treatment methods resulted in a reduction of P. gingivalis counts.
- L-PRF with metronidazole showed superior results in clinical parameters over the study period.
- Microbiological measurements indicated significant decreases in P. gingivalis after treatment.
Takeaway
Doctors tested a new treatment for gum disease using a special gel made from blood and a medicine called metronidazole, and it helped make people's gums healthier.
Methodology
The study involved 24 patients with moderate periodontitis, divided into two groups: one received L-PRF with metronidazole, and the other received L-PRF alone, with clinical and microbiological assessments conducted over six months.
Limitations
The study did not achieve statistically significant differences between the two treatment groups despite observed clinical improvements.
Participant Demographics
Participants were aged 25 to 50, with a majority being male.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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