Development and characterization of novel erythropoiesis stimulating protein (NESP)
2001
Development of a New Erythropoiesis Stimulating Protein
publication
Author Information
Author(s): Egrie J C, Browne J K
Primary Institution: Amgen Inc
Hypothesis
Increasing the carbohydrate content of erythropoietin would lead to a molecule with enhanced biological activity.
Conclusion
The novel erythropoiesis stimulating protein (NESP) has a longer serum half-life and greater potency compared to traditional erythropoietin.
Supporting Evidence
- NESP has an increased molecular weight and greater negative charge compared to rHuEPO.
- NESP can be administered less frequently to achieve the same biological response as rHuEPO.
Takeaway
Scientists created a new version of a protein that helps make red blood cells, and it works better and lasts longer in the body than the old version.
Methodology
Preclinical animal studies were conducted to evaluate the new protein.
Digital Object Identifier (DOI)
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