Impact of Vaccination Timeliness on SARS-CoV-2 Infection Risk Among Healthcare Workers
Author Information
Author(s): Edlira Skrami, Andreas Faragalli, Marica Iommi, Marco Morbidoni, Christina Mancini, Antonella Guidi, Annalisa Cardone, Marco Pompili, Pietro Serafini, Remo Appignanesi, Luigi Ferrante, Flavia Carle
Primary Institution: Università Politecnica delle Marche
Hypothesis
How does vaccination timeliness affect the risk of SARS-CoV-2 infection among healthcare workers?
Conclusion
Vaccination timeliness significantly reduces the risk of SARS-CoV-2 infection among healthcare workers.
Supporting Evidence
- 81.2% of healthcare workers were fully vaccinated by May 31, 2021.
- Vaccination reduced infection risk by 77% compared to unvaccinated individuals.
- Factors associated with full vaccination included age, occupational role, and prior infection.
Takeaway
Getting vaccinated quickly helps keep healthcare workers safe from COVID-19. The sooner they get their shots, the less likely they are to get sick.
Methodology
The study used healthcare utilization databases to analyze vaccination coverage and infection rates among healthcare workers in Italy's Marche Region.
Potential Biases
Possible residual confounding factors may have impacted the results due to the observational nature of the study.
Limitations
The study may have been influenced by nonpharmaceutical interventions and differences in testing probabilities between vaccinated and unvaccinated healthcare workers.
Participant Demographics
The cohort comprised 21,118 healthcare workers aged 18–70, with a median age of 49 years, predominantly female (67.9%) and mostly in good health (69%).
Statistical Information
P-Value
<0.001
Confidence Interval
95% CI: 70–82
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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