Reductive stress on life span extension in C. elegans
2008
Reductive Stress and Life Span in C. elegans
publication
Author Information
Author(s): Ralser Markus, Benjamin Ivor J
Primary Institution: Max Planck Institute for Molecular Genetics
Hypothesis
Reductive stress can prevent calorie-restriction induced life span extension.
Conclusion
Reductive stress may have negative effects on life span extension in various organisms.
Supporting Evidence
- Reductive stress has been linked to reduced life span in various organisms.
- Antioxidants can negate the life span extension effects of caloric restriction.
- Oxidative stress theory of aging remains controversial and not fully understood.
Takeaway
This study suggests that too much of a good thing, like antioxidants, can actually be bad for living longer.
Limitations
The mechanisms of aging and the role of oxidative stress are still poorly understood.
Digital Object Identifier (DOI)
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