The ubiquitination code: a signalling problem
2007
Understanding the Ubiquitination Code
publication
Evidence: moderate
Author Information
Author(s): Wolk Tanja, Sigismund Sara, Penengo Lorenza, Polo Simona
Primary Institution: IFOM, Istituto FIRC di Oncologia Molecolare
Hypothesis
How do cells translate diverse ubiquitin modifications into specific responses?
Conclusion
Ubiquitin regulates various cellular processes, including endocytosis and signaling, through complex modifications.
Supporting Evidence
- Ubiquitin modifications can affect protein localization and activity.
- Different types of ubiquitin chains can signal distinct cellular responses.
- Ubiquitin plays a critical role in the endocytosis of receptor tyrosine kinases.
Takeaway
Ubiquitin is like a signal that tells cells what to do, and it can change how proteins behave in many ways.
Methodology
The review discusses recent studies on ubiquitin modifications and their roles in cellular signaling.
Limitations
The understanding of the specificity of ubiquitin signal recognition is still limited.
Digital Object Identifier (DOI)
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