Receiving three doses of inactivated or mRNA COVID-19 vaccines was associated with lower odds of long COVID symptoms among people with a history of SARS-CoV-2 infection in Hong Kong, China: a cross-sectional survey study
2024

COVID-19 Vaccination and Long COVID Symptoms in Hong Kong

Sample size: 1542 publication 10 minutes Evidence: moderate

Author Information

Author(s): Zheng Chen, Yu Fuk-yuen, Chan Paul Shing-fong, Sun Fenghua, Chen Xiang-Ke, Huang Wendy Ya-Jun, Wong Stephen Heung-Sang, Fang Yuan, Wang Zixin

Primary Institution: The Chinese University of Hong Kong

Hypothesis

Does receiving three doses of COVID-19 vaccines reduce the odds of long COVID symptoms among individuals with a history of SARS-CoV-2 infection?

Conclusion

Receiving three doses of COVID-19 vaccines is associated with lower odds of experiencing long COVID symptoms.

Supporting Evidence

  • 40.9% of participants reported any long COVID symptoms.
  • 16.1% reported three or more types of long COVID symptoms.
  • Older age and female gender were associated with higher odds of long COVID symptoms.

Takeaway

Getting three shots of the COVID-19 vaccine can help people who got sick with COVID-19 feel better and have fewer long-lasting symptoms.

Methodology

This study is a secondary analysis of a cross-sectional online survey conducted among Hong Kong adult residents.

Potential Biases

Self-reported data may introduce recall bias.

Limitations

The study may overestimate long COVID prevalence due to self-selection bias and did not measure the time since last vaccination.

Participant Demographics

Participants were primarily young adults, with 51.3% aged 18-30 and 63.2% female.

Statistical Information

P-Value

0.002

Confidence Interval

0.54, 0.87

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1017/S0950268824001687

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