Atypical Bovine Spongiform Encephalopathies in France (2001–2007)
Author Information
Author(s): Biacabe Anne-Gaëlle, Morignat Eric, Vulin Johann, Calavas Didier, Baron Thierry G.M.
Primary Institution: Agence Française de Sécurité Sanitaire des Aliments
Hypothesis
What is the frequency and molecular characterization of H-type and L-type BSE in France?
Conclusion
The study found that H-type and L-type BSE cases are rare in France, with specific molecular characteristics differing from classic BSE.
Supporting Evidence
- 7 H-type and 6 L-type BSE cases were identified among 645 confirmed cases.
- 0.41 and 0.35 cases of H-type and L-type BSE per million adult cattle tested, respectively.
- All atypical cases were diagnosed in cattle older than 8 years.
Takeaway
Scientists looked at sick cows in France to see how often two unusual types of a brain disease happen, and they found very few cases.
Methodology
A retrospective Western blot study was performed on all confirmed BSE cases diagnosed in France after July 1, 2001.
Potential Biases
Possible differences in pathogenesis of atypical BSEs could result in underestimation of their frequency.
Limitations
The study relied on brainstem examination only, which may lead to underestimation of atypical BSE cases.
Participant Demographics
All atypical cases were detected in cattle older than 8 years.
Digital Object Identifier (DOI)
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