Effectiveness of Meropenem and Avibactam Against Klebsiella pneumoniae
Author Information
Author(s): Strukova Elena N., Portnoy Yury A., Golikova Maria V., Zinner Stephen H.
Primary Institution: Gause Institute of New Antibiotics, Moscow, Russia
Hypothesis
The study investigates the effectiveness of a combination of meropenem and avibactam against carbapenemase-producing Klebsiella pneumoniae.
Conclusion
The combination of meropenem and avibactam shows promising effectiveness against carbapenemase-producing Klebsiella pneumoniae.
Supporting Evidence
- Meropenem alone was ineffective against a carbapenemase-producing strain.
- The addition of avibactam significantly improved the effectiveness of meropenem.
- High inoculum levels increased meropenem MICs, suggesting an inoculum effect.
- Using a pharmacokinetic-based approach for MIC determination provided better predictions of efficacy.
Takeaway
This study looks at how well two medicines, meropenem and avibactam, work together to fight a type of bacteria that is hard to treat.
Methodology
The study used an in vitro hollow-fiber infection model to test the effectiveness of meropenem alone and in combination with avibactam against various strains of Klebsiella pneumoniae.
Limitations
The study did not include a wide range of K. pneumoniae strains or other β-lactam antibiotics.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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