Microvessel Density and Lung Cancer Survival
Author Information
Author(s): Meert A-P, Paesmans M, Martin B, Delmotte P, Berghmans T, Verdebout J-M, Lafitte J-J, Mascaux C, Sculier J-P
Primary Institution: Institut Jules Bordet, Bruxelles, Belgium
Hypothesis
Is microvessel count a prognostic factor for survival in lung cancer patients?
Conclusion
A high microvessel count in lung tumors is a poor prognostic factor for survival in non-small cell lung cancer.
Supporting Evidence
- A high microvessel count was associated with poorer survival outcomes in non-small cell lung cancer.
- Meta-analysis included 14 studies assessing microvessel count via factor VIII, CD34, and CD31.
- Statistical significance was determined using a p-value threshold of less than 0.05.
Takeaway
This study found that more blood vessels in lung tumors mean patients are less likely to survive.
Methodology
A systematic review and meta-analysis of studies assessing microvessel count in lung cancer patients.
Potential Biases
Potential overlap of patient cohorts in different studies could affect the results.
Limitations
The review only included studies published in English or French, which may introduce language bias.
Participant Demographics
Studies included patients with non-small cell lung cancer, with varying stages and histologic subtypes.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI: 1.16–2.84
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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