Redox Behavior of Anticancer Chalcone on a Glassy Carbon Electrode and Evaluation of its Interaction Parameters with DNA
2008
Interaction of Anticancer Chalcone with DNA
publication
Evidence: high
Author Information
Author(s): Shah Afzal Khan, Asad M. Qureshi, Rumana Ansari, Farzana L. Nazar, Muhammad F. Shah, Syed S.
Primary Institution: Quaid-i-Azam University
Hypothesis
How does the anticancer chalcone interact with DNA?
Conclusion
The study confirms that the anticancer chalcone intercalates with DNA, showing a high binding affinity.
Supporting Evidence
- The binding constant of the chalcone-DNA interaction was found to be 6.15 × 10^5 M−1.
- Cyclic voltammetry showed a shift in peak potential indicating drug-DNA interaction.
- Viscometric measurements indicated an increase in DNA viscosity, supporting intercalation.
Takeaway
The anticancer drug chalcone can fit between DNA's building blocks, which might help stop cancer cells from growing.
Methodology
The study used electrochemical, spectroscopic, and viscometric techniques to explore the interaction of chalcone with DNA.
Digital Object Identifier (DOI)
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