TRAIL and Taurolidine Induce Cell Death in Human Fibrosarcoma
Author Information
Author(s): Adrien Daigeler, Christina Brenzel, Daniel Bulut, Anne Geisler, Christoph Hilgert, Marcus Lehnhardt, Hans U Steinau, Annegret Flier, Lars Steinstraesser, Ludger Klein-Hitpass, Ulrich Mittelkötter, Waldemar Uhl, Ansgar M Chromik
Primary Institution: BG-University Hospital Bergmannsheil, Ruhr-University Bochum, Germany
Hypothesis
Can TRAIL and Taurolidine effectively induce apoptosis and decrease proliferation in human fibrosarcoma cells?
Conclusion
TRD and TRAIL are effective in inducing apoptosis and decreasing proliferation in human fibrosarcoma cells.
Supporting Evidence
- TRAIL and Taurolidine significantly increased apoptotic cell death compared to single treatments.
- Gene expression changes were observed in several apoptotic pathways.
- NFKB pathway was identified as a key regulator in the apoptosis induced by TRAIL and Taurolidine.
Takeaway
This study found that two substances, TRAIL and Taurolidine, can help kill cancer cells in a type of tumor called fibrosarcoma.
Methodology
The study used FACS analysis, TUNEL assay, RNA microarray, and Western Blot to assess cell viability, apoptosis, and gene expression.
Statistical Information
P-Value
p = 0.049
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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