Gasdermin D as a Diagnostic Biomarker in Bladder Cancer
Author Information
Author(s): Monika Gudowska-Sawczuk, Sara Pączek, Michał Olkowicz, Jacek Kudelski, Barbara Mroczko
Primary Institution: Medical University of Bialystok, Poland
Hypothesis
The study aims to assess the significance and diagnostic utility of serum GSDM D in bladder cancer.
Conclusion
GSDM D in serum appears to be a valuable diagnostic biomarker for bladder cancer, especially when used alongside other markers.
Supporting Evidence
- The concentrations of GSDM D were nearly twice as high in the serum of bladder cancer patients compared to controls.
- The diagnostic sensitivity of GSDM D was higher than that of CEA.
- GSDM D had an AUC value of 0.741, indicating a reasonably good ability to differentiate between bladder cancer and non-cancerous conditions.
Takeaway
Gasdermin D is a protein that can help doctors find bladder cancer earlier by looking at blood samples.
Methodology
The study analyzed serum samples from 80 individuals, including healthy volunteers and bladder cancer patients, measuring GSDM D levels using immunoassay techniques.
Participant Demographics
The study included 42 males and 8 females with a mean age of 70.4 years for bladder cancer patients, and 17 females and 13 males with a mean age of 44.1 years for healthy controls.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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