4-Chloro-6-methyl-N-(4-methylphenyl)quinolin-2-amine
2011
Study of 4-Chloro-6-methyl-N-(4-methylphenyl)quinolin-2-amine
publication
Evidence: moderate
Author Information
Author(s): Vennila K. N., Prabha K., Manoj M., Prasad K. J. Rajendra, Velmurugan D.
Primary Institution: Centre of Advanced Study in Crystallography and Biophysics, University of Madras
Hypothesis
The title compound was chosen for the X-ray crystallographic study due to its significant biological importance.
Conclusion
The study provides the first structural example of a quinoline derivative with a methyl phenyl moiety attached to an amino group.
Supporting Evidence
- The dihedral angle between the quinoline ring system and the phenyl ring is 50.18°.
- Molecules are linked into chains by N—H⋯N hydrogen bonds.
- The structure shows helical patterns in molecular packing.
Takeaway
This study looks at a special chemical compound that might help in fighting cancer. It shows how the molecules are arranged in a crystal.
Methodology
X-ray crystallography was used to determine the structure of the compound.
Digital Object Identifier (DOI)
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